 |
 |
hi all i've been looking for studies indicating the effects of carbidopa overdose with no success so far i have however, finally found something 'official', stating the optimum carbidopa dosage level; this is extracted from a detailed description of carbidopa-levodopa at the Rxlist web site: ------------------------- DOSAGE AND ADMINISTRATION The optimum daily dosage of Carbidopa-levodopa must be determined by careful titration in each patient. Carbidopa-levodopa tablets are available in a 1:4 ratio of carbidopa to levodopa (Carbidopa-levodopa 25-100) as well as 1:10 ratio (Carbidopa-levodopa 25-250 and Carbidopa-levodopa 10-100). Tablets of the two ratios may be given separately or combined as needed to provide the optimum dosage. Studies show that peripheral dopa decarboxylase is saturated by carbidopa at approximately 70 to 100 mg a day. Patients receiving less than this amount of carbidopa are more likely to experience nausea and vomiting. ------------------------- there seems to be no point in posting the entire 26k article since it appears to be quite old and oriented toward switching patients from levodopa monotherapy [!] to carbidopa-levodopa i am counting my blessings... your cyber-sibling janet janet [log in to unmask]