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Thank you Sid and Janet. It sounds like Dad is receiving close to the max dosage. The ginger ale tip sounds so inviting---maybe he could drop back on the regular rx and take a ginger ale break (like Ken) when he feels the need... On Wed, 12 Nov 1997, Sid Roberts wrote: > On Tue, 11 Nov 1997, Linda Becker wrote: > > > Would someone explain to me what these Sinemet doses (eg. 25/100 and > > 50/200) means? My mom says that Dad is taking 50/200 four times a day. > > That sounds like a lot. Is it? > > Thanks. > > a "Newbie" > > > Hi Linda, > Sinemet is the brand name for Carbidopa-Levodopa. It is the primary > treatment for the symptoms of Parkinson's Disease. It is a combination > drug (name based on the Latin without sin, vomiting emet) where the > carbidopa allows the levodopa to go from the intestine to the blood brain > barrier where the carbidopa stops and the levodopa is converted to > dopamine. > The size of the dosage is expressed as a fraction where the top number is > carbidopa in milligrams and the bottom number is levodopa in milligrams. > There are two types of sinemet: immediate release and controlled release. > The latter always designated by the lettters CR. > The Sinemet CR comes in dosasges of 25/100 and 50/200. Standard Sinemet > comes in dosages of 10/100,25/100, and 25/250. > According to one authority the range of daily dosage is 75-200 mg of > carbidopa; and, 200-1,000 mg of levodopa. > There is, however, a controversy among neurologists as to range of > dosage, and as to what stage of PD the Sinemet should be used. But you > probably are already aware of the controversy. > > -------------------- > Sid Roberts 67/dx3 > [log in to unmask] Youngstown, Ohio >