TOLCAPONE /TASMAR - SILENCE?? I am grateful to those List members who replied to my note of the 29.10.97 and to those who made subsequent independent contributions. Sonia wrote of her experiences on the 31.10.97 reminding us that "the side effects can be very unpleasant" Regrettably, I too have to send in a negative report - so much so that TASMAR has been removed from my list of prescribed medicaments. Of course, I could be one of those statistical blips that Roche refer to in their sales literature published at the time of the TOLCAPONE introduction into Canada - "The most frequent adverse event that leads to discontinuation of therapy was diarrhoea (only five to six per cent discontinued therapy as a result, versus one per cent on placebo". Thank you Judith Richards for sending a copy of the Press Release to the List on the 31,10.97. In my case, TASMAR was prescribed to be taken 3 x 100mg. daily. - starting on the 10.10.97. It was stopped on the 22.10.97. Initially, little was noticed, but from the 16. October onwards, I was having increasing problems with the bowels. As from the 22. October the situation drastically worsened. Since then, I have been plagued with a most disagreeable and enervating diarrhoea. In spite of anti diarrhoea medicines being prescribed on the 01.11.97, it still has not stopped (07.11.97) although hopefully, the worst may be over now. The purpose in reporting these incidents to the List is several :- it is only by learning of others' experiences that one can learn oneself. to substantiate the experience of others who have taken TASMAR to confirm that my attacks of diarrhoea, allegedly caused by the TASMAR, were not trifling matters, they are taking place over a longish period of time and are severe. My general health condition has declined during these last weeks. to highlight the problem so that doctors who may be prescribing TASMAR may themselves be reminded of the risks involved and to suggest that doctors inform their patients accordingly. finally, I suggest that it could be helpful if our messages of concern were to reach the correct departments at Roche both in New Jersey and in Basel In my layman's view, the diarrhoea presents a serious problem that will not go away by either ignoring or belittling it. Should not corrective action to the formula be considered both for medical and commercial reasons? I hope that this report on a personal experience with TASMAR may be useful and a contribution towards a better understanding. With best regards [log in to unmask] (Rae Paterson)