To Joe Bruman et als: Re: MSG The Parkinson Study Group, made up of researchers from the U.S.A. and Canada, is designing a clinical trial to study the safety of using glutamate antagonists to treat PD. Glutamate is an amino acid which causes nerve cells to become active (excitatory neurotransmitter). Researchers have found that when dopamine decreases there is a corresponding increase in activity of the subthalamic nucleus which sends glutamate messages to control movement, which leads to tremors. Researchers think that the increase in glutamate messages could have a toxic effect on nerve cells, hence the search for glutamate antagonists to block the messages. Dr. Carlos Singer, M.D., a consultant to the NPF at the Univ. of Miami, is part of the Parkinson Study Group. Stephan 53/7