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Hi Linda Re the Mirapex: You don't say what strength Mirapex your father is on. My husband Steve(79 years old, diagnosed 24 Sept) started out on .05 Mirapex and was titrating upward as per the schedule that comes with the trial packet from the Neuro. When he was on .25 total per day, he started "melting." He would feel it coming on, and even with me holding him, every muscle in his body turned to jello. He went off all meds for 10 days and then began 1/2 a Sinamet tablet(25/100) twice per day. He has been on that for a week now, and is tolerating it. Ellen Peck [log in to unmask] ---------- > ------------------------------ > > Date: Tue, 11 Nov 1997 22:18:08 -0500 > From: janet paterson <[log in to unmask]> > Subject: Re: Sinemet and Mirapex [for linda carlton] > > hi linda > > you wrote: > >my father is taking 1/2mg 3x a day of Mirapex (for 3 months) and > >25/100 3x a day of Sinement (for 3 weeks). > >He is experiencing a lot of leg weakness, and the inability to walk, > >could this be too much, or what could be causing this problem? > > has he only been on sinemet for three weeks? > if so, this reminds me a bit of steve and ellen peck's problem > with steve having been started on sinemet > at too fast a rate