Julian and Joyce- I was diagnosed two months ago, and my neurologist put me on Selegiline HCL 5mg. daily. A month later he added Amantadine 100mg. twice a day. About two days after I started taking Amantadine, I went into a very severe depression. After a day and a half of tears and general emotional brittleness (I have not been prone to depression at all in the past), I called my neuro and he reduced the Amantadine to one capsule a day. Overnight the depression lifted and I was myself. When you guys talked about trying four 100mg pills a day, I thought I should tell about my experience. The possible downside of reducing my dosage to one capsule a day is that I can't see that the medication is having much effect on my symptoms. But at least I'm not dealing with severe depression. I'll be curious to hear how things turn out, Julian. Ken