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--------------------- ATTN: Barbara Brock --------------------- Rushing to tell you that I have been on the exact dosages of Sinemet and Amantadine (Symmetrel) that Art is taking for nine years and I took Sinemet alone for five years previous to that. The efficacy of these drugs are as good today as they were 14 years ago; therefore, I am not sure whether the disease has not progressed during this time or whether the disease has progressed but the meds have "kept up" with the progres- sion. I have no reason not to feel confident that Sinemet will remain effective for me for many more years. I see nothing wrong with Art trying one of the new drugs without taking Sinemet to see if he does well at this early stage of pd, and if this is what he wishes to do, he should make this known to his doctor. However, if he does not receive the help with this treatment that he desires or feels he needs at this time, I personally feel he should not hesitate to go back to taking Sinemet. I realize others may have had different exper- iences with the early and long-term usage of Sinemet... I am only relaying to you what my experience has been during the 19 years I have had pd. If you or anyone else has any questions, I would be happy to receive them. Warmest Regards, Janice Long 54/20