Dar All, Hi. I have not been keeping up on my reading or lurking, but I need some advice if there is any. My father is nearly 82, has been diagnosed with PD for maybe 12 years. That's another story. Anyway, he was most hard-hit with depression at first - takes Prozac. Recently, he began Mirapex. It did help return his personality but his moevement is not helped at all - may even be worse. His med schedule is: Morning - 1 (20mg) Prozac 1 (.25) Mirapex Noon - 1 (.25) Mirapex a half Clozaril (forgot to get this dose) 3:30 - 1 (20mg) Prozac Dinner - a half (10/100) Sinemet Bedtime - a half Clozaril Recently, the second Prozac had to be ordered because he began getting very depressed and upset again. His right hand's shaking is awful - at times he cannot hold a glass of liquid. The other side is not as bad, but he is frustrated and says it tires him out terribly. To complicate matters, my mother, his primary caregiver, had a serious and permanent loss of vision in her strong eye via veinous occlusion and subsequent neo-vascular glaucoma. What a crzay time. It seems stabilized somewhat now but she will never be the caretaker she was. This puts pressure on him which has to bother him. His doctor is not a movement disorder specialist nor is he the type that welcomes the patient as a partner in his/her own care. I mentioned the listserv and said it seemed to me that PD was really a matter of balancing drugs as much as anything. He said it was not that at all. My father has a history of high sensitivity to PD drugs. So, here's the question: any suggestions? We live in Scranton, Pennsylvania but I question the merit of another evaluation. It would mean going out of town to Philly or New York or Washington. What benefit? He is getting tired and more feeble. Can I do anything? Thanks for ALL your help through this wonderful listserv. Jeanne Hoffman