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Barry Doyle wrote: > > Can a PWP undergoing surgery take Zofran? The patient in question is > early 40s. She currently takes: Sinemet CR 25/100 - 5/day > Parlodel 2.5 mg - 4/day > Selegeline 5 mg - 2/day. > > She will stop the Selegeline three days before surgery and not restart it > until 3 days after. > > It has been suggested she take 1 Zofran tab the night before surgery, > Zofran be administered twice intravenously during the surgery/recovery > period, plus another tab the evening after her surgery. > > She had at least one intravaneous dose (maybe two) of Zofran when she > underwent another surgery last Nov. ; it was effective at stopping the > nausea and she experienced no side effects we know of. At the time she > was taking the Sinemet CR and had stopped her Selegeline dosage three > days before. She had not starting taking Parlodel. > > Thanks. Barry, Zofran (also known as ondansetron) is safe for PWPs. Unlike Compazine, Reglan, Phenergan or other antinauseants used for surgery-related nausea, Zofran does not interact with the dopamine receptors. Zofran blocks serotonin receptors (5-HT3 subtype). Zofran also has few drug interactions and few side effects (the most common is headache: occurs <10%) Another alternative would be Tigan (trimethabenzamide) which is an older anti-nausea medication. Good luck with the surgery.