 |
 |
Debbie, On those increasingly rare nights I sleep well (not tonight), I get up at 06:00 A. M. and take my first 25/100 Sinemet. I feel pretty good for the first 5 minutes and then I go down. About 60 to 75 minutes after I take my first Sinemet I begin dyskinesia, which includes chorea and dystonia. Sometimes this is preceded by a tingling or internal tremor in my feet. Sometimes my toes twitch first, then my legs, then my trunk. Sometimes the chorea is quite violent. The tingling, dystonia, and chorea were much worse when I took two 2.5 mg Parlodel per day, which is not supposed to be a vary large dose. My present dose of Mirapex is not a large dose either, but I seem to be getting a mild form of the same effect I got from Parlodel. 90 minutes after my first Sinemet I feel pretty good, and if I eat only fruit for breakfast and lunch and take my medication on schedule, I feel pretty good the rest of the day. But if I have even just dry cereal with orange juice instead of milk for breakfast, I come down hard at 10:00, and the (sometimes violent) chorea and all the rest of it returns and stays until noon. This is not a good thing at work so I take extra 25/100 Sinemet to avoid it. Four and 1/4 years ago, when was I first diagnosed, I had quite a lot of internal tremor and tingling. I had no visible tremor, and no dyskinesia. The internal went away after a couple of months on Eldepryl. Baldwin, 63/4 8x25/100 carbi/levo-dopa, 3x0.25 mg Mirapex. 5 mg Eldepryl per day [log in to unmask] ---------- From: Debbie White Sent: Sunday, November 23, 1997 8:06 PM To: Multiple recipients of list PARKINSN Subject: Intermal shaking I just got off the phone with my mother Joyce (68/9 months) who, in an effort to start Eldepryl soon, has reduced her Permax by half (so far) (i.e., 1/2 dosages 4x/day) and given up 10 mg Paxil/day altogether. She is still on 4.5 25/100 Sinemet. Both she and my father told me that this has been her worst day yet. She had to stay put the entire day due to increased internal shaking, mostly in her mid-section/stomach area. The only thing she can imagine is that she somehow forgot her afternoon dosage of Permax. She took her evening dose a few minutes ago and is waiting to see whether that will improve things. She mentioned that when she wakes up in the morning, she usually feels pretty good. She takes her meds and then about 1/2 hour after that starts to experience the intermal shaking. Eventually, it gets to a point where she can do what she has to do. I know I have asked about this symptom (side effect??) before, but it seems to me that this may be a side effect of her drugs. Has anyone experienced this as a side effect? This is not a symptom she had when she was first diagnosed. Again, thanks in advance. Debbie White [log in to unmask]