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Gail... You're right, of course, and tho I started out taking a 1/2 tablet by the end of the initial week of usage, that dose had ceased to do the job. The neuro advised me not to move to a stronger dose and I concurred because I was experiencing some PD symptoms in the evenings which appear to have been caused by the Pemoline. I must admit to some difficulty to in accepting the idea that I apparently need a pill to fall asleep and another pill to stay awake. This hadn't occurred to me until I began taking the Pemoline - I welcomed it and hated it at the same time. Hugs at ya.... Barb Mallut [log in to unmask] ---------- From: Wanda & Gail Sent: Monday, November 24, 1997 8:30 AM To: [log in to unmask] Cc: [log in to unmask] Subject: Re: Pemoline Report Barb, I'd like to remind you about something that you already know but it may apply: 1) sleep and awake cycles take at 'least' two weeks to stablelize. 2) when 1 is too much, 1/2 can be better, or 1/4 some help is better than none 3) 'years of bone crushing fatigue' will take a period of adjustment to new found energy, maybe muscle weakness may have resulted and some exercise for endurance will help smooth out the transition period. Just some thoughts, Gail Re:Barb's Pemoline Report: FYI.... I was prescribed the drug PEMOLINE ((last week)) to see if it would alleviate the terrible, bone crushing, daily PD-related fatigue I've lived with for (( the past several years)). Well... there's good news and there's bad news: The good news is the ((drug DID keep me awake in the afternoons)). The bad news is when it wore off in about 4 hours, I crashed into THE most unbelievable sleepiness imaginable! I was WASTED for the rest of the day! Total ZZZZZZZZZZZZZZZZZZZZZZZZZZZ! I experimented with the amount of time between first and second doses during the day and still had the same reaction about 4 hours after taking the initial dose of the day. YIKES!!!! I don't want to struggle on thru a ((reasonable test period)) with this drug to see if I adjust any better to it. I don't like feeling like a ZOMBIE! Adios Pemoline. <yawning> Barb Mallut [log in to unmask]