Can a PWP undergoing surgery take Zofran? The patient in question is early 40s. She currently takes: Sinemet CR 25/100 - 5/day Parlodel 2.5 mg - 4/day Selegeline 5 mg - 2/day. She will stop the Selegeline three days before surgery and not restart it until 3 days after. It has been suggested she take 1 Zofran tab the night before surgery, Zofran be administered twice intravenously during the surgery/recovery period, plus another tab the evening after her surgery. She had at least one intravaneous dose (maybe two) of Zofran when she underwent another surgery last Nov. ; it was effective at stopping the nausea and she experienced no side effects we know of. At the time she was taking the Sinemet CR and had stopped her Selegeline dosage three days before. She had not starting taking Parlodel. Thanks.