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Hey Dale Severance, you wrote: > November 22, 1997 > >I have just taken my first pill of requip. My physician participated in the >clinical trials of this drug at the PDF in NY City and placed me on a >different schedule than that which is recommended by the manuf. Your doc. seems to know his Requip. I took the standard manufacturer's starter pack, but seemed to be getting no benefit! So I increased the dose fairly quickly up to 20 mg per day, and it cut in nicely. However, I started to experience hypersensitivity, of skin and hearing, so I cut back to 15 mg per day, which suits me very well, along with Madopar (Levodopa + benserazide), 1250 mg per day. Keep well. Jeremy > >Prior to today I was taking sinemet 25/100 every three hours, elderpril 5mg >morning and lunch and parlodel 5mg four times a day. >I am experiencing increasing tremours in my left hand, foot curling in with >toes curling under and end of doze movement. > >In the past I have had no difficulty getting started with new meds and I am >fornunate that I am in my 11 year without experienceing any depression. > >Against that back ground we have decided to increase by .25mg the requip >every 2 days instead of ever 7 days as recommended by the manuf. The doctors >reasoning was that requip has some of the properties of parlodel which I have >had no problem with in the past. I also discontinued parlodel immediately or >cold turkey without and phaseing off period. > >I have a real good relationship with Dr. Efraim Perez a movement disorder >specialist. Our conference yesterday lasted about 4 hours including lunch >with the doctor and his staff in the hospital cafeteria.I do a lot of >tangential work with the doctors patients in the hospital and in his private >support group. I mention this as a background to our medical course of >treatment. The doctor is experimenting a little and trusts me to stay with >the medical protocal and to report accurately the results to him. He has >given me the freedom to increase my sinemet intake during this period to >every 2 1/2 hours if I go into off periods until the requip loads up into my >system. > >The doctor advised me that it is a very tough transition period and that I >need to stick it out for at least six weeks. Initially I can expect to >stiffen up significantly and to have increased periods when I am off and the >off periods will be signifiantly longer until the requip loads up in my >system. > >In the evening I attended his support meeting and Dr. Perez overheard me >making plans for breakfast next monday with one of the SG members and over my >shoulder he said i wouldn't wait till monday to have that breakfast. >I hope he was jokeing or oh my God what have I gotten my self into. > >Actually I do not dread the experience and I am anxious to get it on. > >I will report the results weekly if I am able to. > >Is there anyone else taking requip at this accelerated pace? > >I also have seen dramatic results in our support group from two people taking >this drug. One rather young woman has been confined to a wheel chair for >about two years. She has been taking requip for about six weeks and for the >last four weeks has not had to use the wheel chair. She got a round of >applause when she walked into a breakfast social gathering we have between >our monthly support meeting. > >The other example was of an elderly lady who had been in a nursing home for >two years and she is well enough to return to her daughters home. > > >Good luck to all who are giving this drug a try. > > >Dale Severance >[log in to unmask] > -- Jeremy Browne - [log in to unmask] Hampshire, UK