Dear Nancy--there are a number of folks on ReQuip and Peter is one of them. He has been told to add to the dosage VERY slowly, because he had a terrible ex perience with Pramipexole(Mirapex), the other new agonist. This moves me to caution you about the doc not wanting to reduce the Sinemet,"because he feels he's undermedicated". That was what our neuro thought about Mirapex, and he would not reduce the Sinemet, even though I told him that many docs were doing so (had read it on the list). The result was that Peter spent 3ays i n the hospital with a paranoid reaction, after wandering around outside in the middle of the night,thinking something was after him, etc,etc...Our new neuros at an excellent clinic took that experience to heart, and are having him add ReQuip at 1/3 the recommended rate, and when he had a hallucin- ation after a week on one pill a day they cut back Sinemet at once. He had had mild hallucinations on Parlodel, so seems to be sensitive to dopamine overload, though he was "undermedicated" and never got dyskinetic. On the other hand, one man on the list is adding ReQuip at a FASTER rate than recommen ded, under very careful supervision--he has NOT had trouble with other agonists.. It's so very individual, and I would only want you to be aware that you should watch how things go VERY carefully--I wouldn't want anyone to have to go through what we did! Camilla Flintermann, CG for Peter, 79/8, Oxford,Ohio [log in to unmask] * * * * * * * * * * * * * * "Ask me about the CARE list for PD caregivers!" * * * * * * * * * * * * * *