My mother Joyce (68/9 months) saw her doctor today after a bad week and he is hoping she'll get off Permax completely within a few days (she's been working to get off it awhile now); he's going to try another agonist -- Mirapex or Requip. In the past few days she tried something she hadn't before -- taking a extra 1/4 Sinemet in between doses when things are bad. It helped a bit. Her doctor has decided that effective tomorrow she's switching over to Sinemet CR, which will increase her daily dosage a bit. (Also, she was taking the generic version, which doesn't come in a CR version.) What I'm wondering is -- should she expect anything noteworthy in switching over to Sinemet CR? Thanks. Debbie White [log in to unmask]