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Nancy and all, I am sorry to be so vague in this response, but it did take 5 1/2 weeks before we noticed any significant positive effects. From the beginning he became very agitated, irritable and had hallucinations. However, he was on an extremely high dose of sinemet and baclofen because the severe infection that he had caused him to freeze up in a catatonic state. So we have had to work down the sinemet and work up the Requip. On Wednesday, the day before Thanksgiving was the first day to see a remarkable difference in him. He is now moving much more rapidly (although he is shaking today, which in indicative of overdose). His balance is improved and he is again feeding himself. He is less depressed and tired. He did complain of a little ache this morning, but was relieved with 2 Nuprin. He is able to move himself around in bed more and turn from side to side. He still cannot walk yet, because we haven't got his knees stretched completely straight yet. (Almost) I will report more later in the week. Barb Nancy Burnham wrote: > For those of you who are having a good response to Requip I was wondering > how long it took, what symptoms made you cut back on Sinemet. Don is just > about through with the third week. He hasn't noticed any thing great yet. > Has been more tired, sometimes dizzy and has less balance and more tremors. > He is still taking the same amount of Sinemet, because these symptoms > doesn't sound to me like they are caused by too much. Barbara you mentioned > 6 weeks, does it take that long to notice any improvement. Appreciate any > help. Nancy B cg for Don 63/13 ([log in to unmask])