Elf,=20
Here is a medline abstract concerning lipoic acid. Note the mention of
neurodegeneration. That's us! Judging from everything I've seen about
lipoic acid, it seems that a dish of spinach and a lb of lipoic acid per day
is all you need to meet your daily nutitional needs :-)
Ron Reiner
-------------------------------------------------
Title=20
alpha-Lipoic acid as a biological antioxidant.=20
Author=20
Packer L; Witt EH; Tritschler HJ=20
Address=20
Department of Molecular & Cell Biology, University of California,
Berkeley 94720, USA.=20
Source=20
Free Radic Biol Med, 19(2):227-50 1995 Aug=20
Abstract=20
alpha-Lipoic acid, which plays an essential role in mitochondrial
dehydrogenase reactions, has recently gained considerable attention as
an antioxidant. Lipoate, or its reduced form, dihydrolipoate, reacts
with reactive oxygen species such as superoxide radicals, hydroxyl
radicals, hypochlorous acid, peroxyl radicals, and singlet oxygen. It
also protects membranes by interacting with vitamin C and glutathione,
which may in turn recycle vitamin E. In addition to its antioxidant
activities, dihydrolipoate may exert prooxidant actions through
reduction of iron. alpha-Lipoic acid administration has been shown to
be beneficial in a number of oxidative stress models such as
ischemia-reperfusion injury, diabetes (both alpha-lipoic acid and
dihydrolipoic acid exhibit hydrophobic binding to proteins such as
albumin, which can prevent glycation reactions), cataract formation,
HIV activation, neurodegeneration, and radiation injury. Furthermore,
lipoate can function as a redox regulator of proteins such as
myoglobin, prolactin, thioredoxin and NF-kappa B transcription factor.
We review the properties of lipoate in terms of (1) reactions with
reactive oxygen species; (2) interactions with other antioxidants; (3)
beneficial effects in oxidative stress models or clinical conditions.=20
Language=20
Eng=20
Unique Identifier=20
95377664=20
MESH Headings=20
Animal; Antioxidants (*); Disease; Human; Hydroxyl Radical; Molecular
Structure; Reactive Oxygen Species; Support, Non-U.S. Gov't; Support,
U.S. Gov't, P.H.S.; Thioctic Acid (*/CH/ME/PD/TU)=20
Publication Type=20
JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL=20
ISSN=20
0891-5849=20
Country of Publication=20
UNITED STATES=20
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At 12:29 AM 12/4/97 EST, you wrote:
>Ron,
> If it's possiable would you mind sending more detailed info on "lipoic=
acid"
>...or directing me to a website that has real information about this=
substance
><can ya tell I don't wanna (unless I have to) scroll thru "try me, buy me"
>ads> ... Thanks ... Elf in TN...Romona
> http://members.aol.com/elf808/index.html <---newbie webpage but it's in
>color <G>
>Elf wife to Tony (my hero), and mom to Tori (age 9, nda), Zach (age 7,
>multichallenged), Cory (age5, multichallenged). The boys have no definative=
Dx
>but several labels... Ataxia,Nystagmus, Strubismus, Dystonia, Parkinsonism,
>Asthma, Execma, Hypotonia, Spasticity....ect Collectively the
>Dystonia/Parkinsonism effects the boys from eyes to toes and progressing
>steadily. Currently Cory & Zach are taking Sinemet, Lodosyn and Cory has=
had 4
>rounds of Botox, uses a walker or WC for mobility.
>In a message dated 97-12-03 15:54:18 EST, you write:
>
><<
> Why is everyone so concerned about getting Vit E and C to the brain. If=
you
> think that antioxidants will help, just take lipoic acid. It not only
> reaches the brain, it has been shown to reach the substantia nigra. It is=
a
> very powerful antioxidant and it recycles E which recycles C.
>
> Plus it generates L-glutatione which is scarce in PD people. It also
> chelates Iron.
>
> Builds strong brains in 4 ways!
>
> Ron Reiner (49/2) >>
>
>
