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The epinepherine which is often mixed with the local anesthetic used in dental work theoretically can interact with selegiline. It is used to keep the blood vessels around the dental work constricted. Most dentists will know this and you should ask them to avoid the combination drug and just inject pure anesthetic without epinephrine. Charlie Stephan Schwartz wrote: > > Hello George: You wrote- > >>> George Campbell <[log in to unmask]> > 12/05/97 12:17am >>> > >>>I have to get a root canal. What pain medications and > antibiotics can be > used with the following drugs? > Demadex-20 mg > Potassium-10 meq > Eldepryl-5 mg > Sinemet-25mg/100 x3 > Verapamil-240 mg > Norvasc-10 mg > allopurinol-300 mg > study drug possibly pramipexole twice daily<<< > > George: > Local anesthisa is not ruled out for PD patients getting > dental work. > Be aware that the pain killer Demerol has been reported > to cause an interaction with Eldepryl (selegiline) in rare > cases. > Dentists require full disclosure by the PWP of all the PD > medications and then they should consult with the > neurologist to get medical clearance before major work, such > as root canal. > The American Parkinson Disease Association in NYC > publishes a list of contraindicated drugs for PWPs. Call > 1-800-223-2732. > Good luck! Stephan 53/7 -- CHARLES T. MEYER, M.D. Middleton, WI [log in to unmask]