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In a message dated 97-12-07 20:09:20 EST, you write: << He is taking John off of Senemet and putting him on Requip. >> My understanding of the therapy is to provide the missing L-Dopa via the Sinemet, and Requip can be used as an adjunct agonist interspersed with it. As an agonist, it acts as a surrogate L-dopa and increases the effectiveness of the drug. Requip is not a substitute for L-Dopa! Michel Margosis 'Carpe Diem'