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Hello Susan, OH so sorry, first today I have seen your e-mail. I promise to send you e-mail laater today or tomorrow OK. Kind regards Sonia ---------- > Fra: Susan M. Hogger-Chamberlain <[log in to unmask]> > Til: Multiple recipients of list PARKINSN <[log in to unmask]> > Emne: Tasmar/Tolcapone > Dato: 30. november 1997 12:51 > > Dear Sonia > > I am very pleased to read that you are now getting on better on Tasmar. > > I am also in my third week of taking it. I started on Wednesday 12th > November and began very slowly by taking one 100mg Tolcapone for five days > and then took two per day for the next four days. Then on Friday 21st > November I took three per day which I am still on. I have not had any > diarrhoea problems but I have rather a lot of involuntary movements. > > As far as improvement of my PD goes (I have had it for 12 years and am 44) - > I was experiencing a lot of irregular on/off's before and I now have longer > on's but still have uncomfortable off's but not so many, so I am hopeful that > this will continue. I feel I have more tremor when off though, particularly > first thing in the morning. > > I take Sinemet CR 25/100 four times a day and have been able to spread the > periods between doses out but it is still hit and miss as sometimes I seem to > be able to go up to 5 hours in between and then sometimes only 3 or so. > Before going on Tolcapone I was taking the dopamine agonist Lisuride (I > haven't read of anyone else on the list being on this) but my neuro though it > better that I stopped it before going on Tolcapone and so I slowly came off > it over three weeks and then had a week of just taking Sinemet CR - this was > a week of hell - really bad long seize ups - so I was glad to start taking > Tolcapone. I take the Tolcapone at about 6-7 hour intervals. > > At the moment I do not feel I have any more energy which I was hoping for > since I feel tired a lot of the time but maybe this will improve. > > I also take the anti-depressant Clomipramine which I think makes me sleepy. > > What strength Tolcapone are you on and when do you take them and what other > medications do you take? > > Are there many others on the list on Tolcapone? I haven't seen many postings > about it - mind you I'm a bit behind with my reading so may have missed > something. > > Its all very hit and miss isn't it? We are all so different and react to the > medications in different ways don't we? > > Anyway best wishes to you Sonia and I look forward to hearing from you. > > I have also sent this to the list. > > Susan H-C 44/12 > UK