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Nancy, Generic drugs are regulated by the FDA and are supposed to be bioequivalent (having the same action in the body). For the most part this is true. However in some rare cases while the drug may be the same the preparation is different (e.g. packed so tight that it is not absorbed. When I was practicing I prescribed generically and had little trouble. I personally take generic sinemet and have had no trouble with it. It is quite a bit less expensive. In general my advise to people who wish to switch to a generic drug is be aware that changes either way may occur but are unlikely. Remember with PD our symptoms are constantly fluctuating so don't jump to conclusions too fast. Also one should try to stay on a generic made by the same company from prescription to prescription. Drug companies make a tremendous mark up on their drugs. They are entitled to recoup their losses on drugs that haven't panned out and their development costs. You can be sure that after that they take a significant profit. They attempt to convince us that there are significant benefits by taking their brand but that is very rarely true. Charlie Nancy Burnham wrote: > > It anyone using the generic Sinemet? Does it work the same. Our insurance > has just started a new program. Meds listed on their list are $12.00 per > month, but the Sinemet ,which it now available in the generic type, was > $21.83. If you request the generic then it is $12.00. Nancy B cg for Don > 63/13. > Helena, MT > [log in to unmask] -- CHARLES T. MEYER, M.D. Middleton, WI [log in to unmask]