My husband Ron was diagnosed with Parkinson's 5 years ago, although we are sure that he has had it for about 8 years. He is 65 years old. It started with tremors in his right leg, then it moved to his left leg and slight tremors in his right hand. He takes Sinemet CR 200/50, 1 tablet 4 times a day Levodopa/Carbidopa 100/25 1 tablet in the morning Bromocriptine 2.5mg-12 tablets daily Domperidone 10mg - 1 tablet 4 times a day Vasotec 5mg - 1 tablet daily Lately he has been having quite a lot of difficulty with off periods, therefore his quality of life has been declining. He is a patient at the Movement Disorders Clinic at U.B.C. in Vancouver, B.C. Last Friday he started on Tolcapone, 1 tablet 4 times a day. The improvement in his condition is just unbelievable. His off periods have all but disappeared, his energy level has much improved, he is back to his old self again. He even looks so much better. He has had no side effects yet, we understand that not everyone suffers with side effects, so we are keeping are fingers crossed at the moment. Bev Keegan bkeegan@smartt,com