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Brian Collins has suggested that all agonists are much the same except for their side effects.My own experience is that there could be differences.I have mainly been on Pergolide but had a little flirtation with Ropinerol.The differences showed up in an 'objective' test I had devised for myself which involved screwing a bolt all the way up a 2 inch thread and timing my performance right hand against left.Right hand has always remained reasonbly constant under all conditions but left hand performance( it's my left side which is effected) can vary greatly according to the efficacy of my medication At times the left hand has been almost as good as the right hand but at it's worst four times as slow.There is some correlation between the results of this speed test and one's own more subjective assessment of 'how do I feel and how well am I functioning.' Now whereas sinmet only gave me a poor speed result, sinemet plus pergolide at 3 mg a day gave me excellent left hand results so that I was able to resume piano playing.Sinemet and Ropinerol at full dose however did not help my left hand speed which settled at very much slower than my right hand.Ropinerol also resulted in more dyskenesia.Pure speculation suggests that this might be something to do with the different receptors sensitive to the agonists.Of course little amateur experiments like the above proove nothing and need to be properly done under controlled conditions.But they can be fun. David Langridge