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In what way is an excess of this detrimental. My husband's doctor switched him from 25/100 to 10/100 (about 8 a day) and left the five 50/200 CRs alone. This was the same time he tried Mirapex. And things didn't work out so well. Now we're back on the 25/100 and trying Mirapex with some better results. I don't think it was a good idea to make two changes at once. Maybe we should try the 10/100s again? Carol Horner