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Jennifer - I'm so sorry to hear of your uncle's alienation from the rest of his family. I have had pd for 15 years and for the past two or three years the strain on my wife and our four grown children has been very hard. If anything, however, we are closer now than ever. Without question a chronic illness such as pd profoundly alters relationships, but with every loss comes a gain for those who have eyes to see. For the past five years my wife and I have spoken to second year medical students at Harvard Medical School as part of their lecture section on neurology. I talk about my symptoms; she talks about her role as caregiver and the relationship of the family to the patient. Her remarks are as important as mine. She gets the more interesting questions from the students. George Andes 64/15 and still counting.