Stephen.... The following is a "for what it's worth" comment: Tho I've had PD for approximately 22 years the disease has apparently progressed at a much slower rate for me than it has for your dad. Also, I'm nearly 20 years younger than he is... I've had a unilateral pallidotomy with excellent results. My daily PD-drug intake is much less than your father is taking. That said, I began taking CQ10 (Coenzyme Q10), admittedly with some skepticism, about 6 or 7 months ago because I was beginning to experience memory loss (forgetting individual words I'd used for years, however , infrequently). Please note I attribute the memory loss as much to job-related stress as to the PD. After taking ONE 30 mg CQ10 daily for about three months I noticed a slight (SLIGHT!) improvement in that while I still had to occasionally grope for a familiar word, it wasn't happening quite as frequently as it did prior to beginning the CQ10. At that point I added in a second 30 mg CQ10 daily and noticed another SLIGHT improvement above the original. With the above as incentive, 4 months ago I added two 60 mg. Ginkgo Biloba caplets daily to my supplement regimen, and have noticed further SLIGHT improvements. NOTE---> I believe because total improvement overall is COMFORTING emotionally, in part THAT eased the stress induced by the original memory loss. Therefore, while I DO credit the addition of both CQ10 AND Ginkgo Biloba to my daily diet I believe improvement is not TOTALLY due to the supplements (that's an educated guess... I ain't no doctor!) The above is my own experience with memory loss and CQ10, plus Ginkgo Biloba. I have absolutely no idea if your father would benefit from the addition of one or both of these supplements to his daily regimen. Stephen, m'friend, I think one of the most difficult things we have to accept in life is either our own personal losses and/or the loss of the parent we known all these years while that parent is still LIVING. I strongly empathize with you and your father because not only do I have Parkinson's but my mother has had what is now severe "minor" stroke-induced dementia for over 10 years. It's terrible to watch someone we love decline so much over the years till they reach a point where they cannot recall events that just happened a moment ago. Even worse is when their family and friends of a lifetime stop calling or visiting them because "they wouldn't remember anyway." (Hey! let's get honest - those friends are scared of the dementia themselves or just don't CARE enough) Finally, Stephen, I think besides seeing that they get decent medical help about the only other thing we can do for someone having dementia is to comfort them if and/or when they express their own fears of what's happening to them, and to not make it TOO easy for them to give up their own autonomy while protecting them at the same time. Barb Mallut [log in to unmask] ---------- From: Parkinson's Information Exchange on behalf of Direct Imagination Sent: Tuesday, December 23, 1997 9:06 AM To: Multiple recipients of list PARKINSN Subject: CQ10 and PD A few months ago there were quite a few new items regarding Coenzyme Q10. My father (72) has had PD for about 15 years, and is having a lot of trouble with both dementia and short term memory. Does anyone have any experience with CQ10 and advanced PD, and recommendation with with how much CQ10 to take? Thanks. Stephen Hubbard [log in to unmask] (213) 217-7764 Ray Hubbard and his medications 200 mg of CR 6 x day 250 mg Sinemat 6 x day + 1/2 at 2 am 2.5 mg Parlodel 3x day 50 mg 1.5 per day Zolof 0.125 mg Lanoxin per day