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Jennifer, I hope you realize that many of the symptoms of PD can cause a person to alienate others, who don't understand what is happening to the PWP. The lack of facial expression, for example, might be intepreted as disinterest. Also, some medications can cause a PWP to have personality changes. Your uncle needs his family more than ever and I hope he realizes that your interest in his struggles with Parkinson's can lead to a better quality of life for him. Welcome to the list. [log in to unmask]