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Joy Graham wrote: > On a related topic: There are many theories about putting PD medications > into the system. One school believes that a constant supply of levodopa > such as you get in the slow release (Sinemet CR or Madopar HBS) is more > beneficial in the long run than the stops and starts of regular dosing. Joy, I have found that the actual data of blood plasma concentration of the early testing of CR Sinemet compared to regular Sinemet (November 1989 Neurology 39 (suppl 2) page 25 article: "Pharmacokinetics and bioavailability of SinemetCR: A summary of hunman studies" Yeh, August, Bush, Lasseter, Musson, Schwartz, smith and Titus) does not indicate that CR gives a "constant supply of levodopa". My plots and comments on the information can be found: http://www.ridgecrest.ca.us/~rfvetter/levoplas.html If you or anyone has information about Madopar HBS, I would like to acquire such. There is a great variability in the data re plasma concentration using CR. I have no data on any of the Madopar medications. -- Ron Vetter 1936, '84 PD dz paradise is feeling good, not a place to go [log in to unmask] http://www.ridgecrest.ca.us/~rfvetter