At 06:03 PM 12/31/97 +0000, David Langridge wrote: >brain operates (In the areas relevant to PD) that I have read. After >>that he goes into his drug holiday mode, and I stop reading. To put it >>delicately, I think it is rubbish. >> It appears to me that people who say that they do benefit are those who >>are taking what I regard as an overdose of levodopa. It is possible for >>some PWPs to take an overdose first thing in the morning (They often talk >>about the 'tablets cutting in' as they go zooming through the ideal dose >>on the way to the overdose). By the occasional tablet administered at the >>right time, it is possible to stay in this overdosed state most of the day. >>However, 'What goes up must eventually come down', and this is where the >>trouble starts: the dyskinesias have to be faced, and seem to occur as the >>PWP comes back down through the various levels to essentially an un-dosed >>condition. >> > >Brian > >So this much thrashed out subject ' diphasic dyskinesia' now under 'drug >holidays' rears it's ugly head.This message is just to balance the input for >newcomers and state that I believe your theory is flawed ( I won't use your >rather stronger criticism of Mr McGoon) >Simply to claim that overdosing is the cause of end of dose dyskinesia is >far too simplistic and though it might be based on your own limited personal >experience there are far to many descriptions of this phenomenom to be >lightly dismissed. I have described previously how even the smallest dose of >sinemet can produce distressing end of term dyskinesia and sometimes even >delayed for an hour or two and continuing for as long two hours.Strangely >my last experience was 3 hours after taking a last half 25.100 tablet and >was the severest yet lasting a good hour. I blamed the severity on some >acupuncture treatment I had received in the afternoon for Sciatica- it >seemed to have stirred up the chemistry. > >Anyhow for those of us with this reaction a drug holiday can be a blessed >relief and the message from Wesley describing his own experience closely >mirrored mine. > >Ida where are you?* > >David Langridge > >* Ida Kamphuis - a very forceful critiquess of the Collins dogma. > david i don't how to reach you only this way. 73/26 for me. i do not take more or less than my nero says. i believe i have less up and douwn than most. i do know i stasted out takeing to much simment. want to be like others. took about 4yrs to get me regulated i take 25/250 4times a day rest i won.t say. my meds is allmost like eating a meal. as of now am loosing use of my legs,and can't remmer a lot but working on it [log in to unmask] 73/26 lima,ohio I.Y.Q.don&vivian love of my life ****************** * best meds for pwp * * lots of love