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On Wed 31 Dec, David Langridge wrote: > brain operates (In the areas relevant to PD) that I have read. After > >that he goes into his drug holiday mode, and I stop reading. To put it > >delicately, I think it is rubbish. > > It appears to me that people who say that they do benefit are those who > >are taking what I regard as an overdose of levodopa. It is possible for > >some PWPs to take an overdose first thing in the morning (They often talk > >about the 'tablets cutting in' as they go zooming through the ideal dose > >on the way to the overdose). By the occasional tablet administered at the > >right time, it is possible to stay in this overdosed state most of the day. > >However, 'What goes up must eventually come down', and this is where the > >trouble starts: the dyskinesias have to be faced, and seem to occur as the > >PWP comes back down through the various levels to essentially an un-dosed > >condition. > > > > Brian > > So this much thrashed out subject ' diphasic dyskinesia' now under 'drug > holidays' rears it's ugly head.This message is just to balance the input for > newcomers and state that I believe your theory is flawed ( I won't use your > rather stronger criticism of Mr McGoon) > Simply to claim that overdosing is the cause of end of dose dyskinesia is > far too simplistic and though it might be based on your own limited personal > experience there are far to many descriptions of this phenomenom to be > lightly dismissed. I have described previously how even the smallest dose of > sinemet can produce distressing end of term dyskinesia and sometimes even > delayed for an hour or two and continuing for as long two hours.Strangely > my last experience was 3 hours after taking a last half 25.100 tablet and > was the severest yet lasting a good hour. I blamed the severity on some > acupuncture treatment I had received in the afternoon for Sciatica- it > seemed to have stirred up the chemistry. > > Anyhow for those of us with this reaction a drug holiday can be a blessed > relief and the message from Wesley describing his own experience closely > mirrored mine. > > Ida where are you?* > > David Langridge > > * Ida Kamphuis - a very forceful critiquess of the Collins dogma. > > > Hello David, what a surprise to hear from you. I think you will find that I do not refer to people who suffer from diphasic dyskinesia. I was referring to another group who are unfortunate enough to have neuros who are convinced that there is no 'middle road' regime (This is where I operate), and so, with virtually no reference to the patient's requirements, they pump in a big starter to get the overdose going , and you know the rest. These people are being overdosed regularly, and I am concerned that it may have an adverse long term effect on the dopamine system. I am interested to learn that you do get a benefit from a drug holiday, because I certainly don't. Regards, -- Brian Collins <[log in to unmask]>