Hello Wesley, your experiences do indeed seem to be typical of the condition which I described, and remind me of my condition when I started to get to the tricky time of 6 or 7 years with PD. I was taking a mixture of tablets, and found it impossible to make sense of my reactions to the tablets. This is why I wrote my program - to help me with the analysis, with such success (in my case) that I decided to try it out on a few volunteers to see if I could possibly help them. Since I joined the list, about 2 years ago, I have tried to help about 20 people, with varying degrees of success. About 15 of those I would say felt that they had gained some benefit from the exercise. To avoid repeating myself too many times, anyone who is interested in finding out more about my program, and who can 'surf the web' will find a detailed exposition of my program (And a lot of interesting articles from other people as well) on Simon Coles' excellent web site: <http://james.parkinsons.org.uk> Everyone can understand a simple observation that: If you can identify a dosage regime which clearly produces an overdose condition, then somewhere between that regime and no tablets at all, there should be an ideal regime which produces just the required response : you feel 'normal'. To get technical for a moment, the assumption in my statement is that there is a clearly defined 'ideal flow' condition to which one can iterate, based on observation of the subject's response. In reality there may be a number of 'false trails' on the way to the ideal trail, but my philosophy is to first, see if the simple assumption works, and then if that fails think again. I think the reasons why more people do no find my 'Ideal path' by taking tablets as prescribed by their doctor are two-fold: One is the very real difficulty of understanding what is happening to someone with PD if they don't have the condition, and the other is the (to my mind) naive belief that a dosage rate to hit the 'ideal' dosage can be achieved by somehow juggling whole numbers of tablets. You will get nowhere by a logic which says for instance ' If one tablet is not enough, try two' or ' If one tablet every 4 hours is not enough, try one every 3 hours.' People simply do not come calibrated in whole numbers of tablets. The rule which works for me, for instance, is: Take 1.5 Madopar 62.5, every 2 hours. In my present condition (19 yrs since diagnosis, 1.75 tablets would give me diskynesias and 1.25 tablets would fail to switch me On. But if I get it right-Bingo: I can walk, drive, and still function pretty well. Just to complete the story, I have of course gone further downhill since I did that analysis, and I have compensated for that by taking Pergolide (Permax), slowy increasing the dosage as my personal contribution declined, so that I now take the same madopar, plus 3.5 milli gm of Permax. The fact that I have been able to take 3,5 mg of Permax with no noticeable loss of operating margin shows that Permax works. Sorry, long winded as usual Regards -- B J Collins <[log in to unmask]>