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Thanks to everyone who has written both to me and to the PDNET about Larodopa. According to my ND there are several new drugs, on the order of Madopar, which will be available in the U.S. by Spring. Also according to my ND, nausea is the only thing he is concerned about, since I'm starting on a very small dose of Levodopa and I will be the one to increase it. I picked up my Larodopa last night late so I waited till this morning to start on the new meds. So far so good. Ivan, I think I have a unique problem, which most PWP won't have, I have a canernous hemangioma in my liver, which does indeed, cause me many problems. I was probably born with it, but of course no one knows for certain. I wouldn't suggest to anyone to have the test to find out, it hurt like H***. The hemangioma caused me to think the pain of the ruptured sigmoid colon was only the hemangioma acting up, and this time, it made me ignore the purpura, which according to the ND, is caused by Carbidopa. I just thought having purple ankles and lips was a part of the hemangioma and old age. NOT!!! My New Year's resolution this year is to tell my ND when I notice ANYTHING out of the ordinary, instead of waiting 6 months, which I seem to be prone to do. My other symptoms, which did send me back to the ND were: 1. Feeling as if I had the aftermath of an Asthma attack, this went on for about a week, and I hadn't even had an Asthma attack. 2. Very blurred vision, starting one to one and a half hours after taking Sinemet. I traced this for a week before calling the ND. 3. Purpura, which I completly ignored for 6 months, I'd slap a bandage on it when it bled and went on. I have no idea why I thought I should have purple ankles and arms.But when it started in on my face and lips, I did become concerned. (Vanity thy name is Woman)????? I will give the definition of Purpura from the Taber's Cyclopedic Medical Dictionary for those of you who don't have access to a library. PURPURA (pur pu ra): Condition with various manifestations and diverse causes, characterized by hemorrhages into the skin, mucous membranes, internal organs, and other tissues. Hemorrhage into the skin shows red, darkening into purple, then brownish-yellow and finally disappearing in 2 to 3 weeks. Areas of discoloration do not disappear under pressure. The Lancet, the British Medical Journal had a good article on Schonlein-Henoch Purpura and Carbidopa being the cause. Of course my ND already knew all about it, but I did some research on the subject of purpura before I found it. If anyone would be interested in the article, let me know and I'll email it to you. I'm on digest now, so you'll have to contact me directly or it will be a day or two before I get my email read. <[log in to unmask]> Marjorie Moorefield just another librarian with PD 65/9