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I have recently been suffering with what turns out to be an adverse reaction to the Carbodopa part of the Sinemet, and my ND changed me over to Larodopa. I'm on a forced drug holiday, since none of the pharmacies stock Larodopa anymore, but it is possible for them to order it. However, I won't be able to get it before Friday after work. I'm not going to say a drug holiday is bad for everyone, but I will say from personal experience, that for me at least, its a torture which I really don't need at this time!! Larodopa is Levodopa with out the Carbodopa, it was used widely in the 70's and it will cross the blood/brain barrier alone, but it will require twice the dosage of what I had to take of the Sinemet. Maybe one of the reasons Brian Collins is lucky enough to not have had problems is that he is fortunate enough to have a product which doesn't contain Carbodopa. Unfortunately it isn't available in the U.S. How I wish it were!!! Now, my question is, since I can't take anything to counteract the nausea, because it would bind with the levodopa and stop it from working effectively, and since Levodopa taken alone, and in the quantities I will have to take, will cause nausea, can anyone who has taken it give me any suggestions? My ND said to take it WITH meals. BTW, I can't take a PD agnoist because of other health problems, so I'm not able to even try Mirapex or Requip. Thanks in advance, Marjorie Moorefield, just another librarian with PD 65/9