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Hello Manfred, One more comment: > 2. My prescription (which I have not yet taken) is as follows: one tablet > of Sinemet CR 100/25 a day in the morning after a meal. If the release > time of Sinemet CR is 2 to 5 hours what happens for the rest of the 24 > hours? Isn't it better to take Sinemet CR before a meal? > When we start medication (or change prescription) there is generally an initiation or a weaning off where you introduce the change very gradually over a period of weeks. This minimizes side effects. If I'm correct in assuming your prescription would escalate over a few weeks to Sinemet CR 100/25 taken 3 or 4 times daily then that would sound normal. I hope this is constructive. Good health; Murray [log in to unmask]