Well my dad is no better on the Mirapex -he is now dizzy almost constantly. So we went from a miracle drug to almost back to where we were before on the Sinemet. (Although that was a nightmare !) It seemed he was doing good somewhere in the middle - but the Neuro insists he HAS to be on the higher dose - or there is no point being on it at all. So he will be switching the next neuro visit I am sure. Now I know a number of you have switched - do you ramp down on one while increasing the other ? Does he have to go down to NO drug before starting ReQuip ? (That could be a night mare too !) What is the general reaction to ReQuip ? My general impression is that it is no better than Mirapex ... should we switch - or stick with the MIrapex and play more with the dosage ? He' scurretnly at 0.5mg/3X a day (breakfast lunch and dinner - which as I've mentioned in the passed I'm worried might be too close together). Dad is getting fed up with being sick all the time. Please - any advice /experiences welcolm. We just want dad back again ! Thanks donna (daughter of PD dad 74/1yr) ------------------------------------------------------------------------------ - Donna Bassolino-Klimas, Ph.D. Bristol Myers Squibb Pharma. Res. Inst. Department of Macromolecular Structure P.O. Box 4000 Room H3812 Princeton, N.J. 08543 4000 (609) 252 4413 INTERNET: [log in to unmask] ------------------------------------------------------------------------------