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Dear Jonathan and Suzanne, Sorry to hear about your mom's recent
exacerbations of symptoms! You mentioned, your brother in Calf. (is he mom's
primary CG?) feels she is "in the end stage."  Evidently she has had an
increase in symptoms in recent weeks and at this time seems to have a lot of
dementia. In my experience and to my knowledge, there doesn't seem to be any
descrete "end stage" associated with the disease, but rather perhaps a
culmination of physical & psychological factors weakening the immune system
and inviting onset of various other potentially fatal illnesses. I could be
all wet here, but I was under the impression Parkinson's is *not* a "fatal
disease," per se. So that might be some comfort or reassurance. Or maybe
not. As to the dementia, though, after reading your post my immediate
reaction was to think of my father's experience in taking just a truckload
of different medications, and the possible interactions of these drugs... My
Dad has very definitely experienced significant dementia and even psychosis
at various times, due to the drug interactions of medications he's taken.
Several have made him hallucinate. In most cases he has become very aware of
these side effects rather quickly, and subsequently discontinued the med. A
few, however, have made him seem to "really be losing it," without anybody
really noticing -- until his behaviors became quite bizarre. After being
withdrawn from some new med some Dr may have prescribed (without knowing the
clinical hx, etc), Dad has rather quickly and consistently returned to
whatever state of "normal" is possible for someone with advanced PD. As with
an "end stage" therefore, I have the idea that dementia per se is not
symptomatic or characteristic of PD, but may frequently be associated with
multiple drug interactions. Talk with your Mom's physicians and try to get a
handle on their understanding of the possible adverse effects of some of the
meds she's on, when taken in combination.

Now allow me to reveal my cynicism for a moment: I'd bet your mom sees at
least 3 or 4 different Docs, all "specialists" in one area or another. I'd
bet half of them don't have the faintest idea what the others are
prescribeing, or how any new medications they might initiate may interact
with those Mom is already taking. in considering your mom's "dementia," that
would be the *first thing* I'd want to investigate! Good luck. And I hope
your mom feels more functional soon!

Roger