Someone asked a couple of days back if Requip came in other than 0.25 mg tablets. I can confirm that it comes in 1mg tablets; my regimen is currently 1mg Requip & 1 50/200 Sinemet CR - Three times per day I too have noticed a slight tendency to have a headache after taking my meds which did not occur when I was only taking the Sinemet (hence the Requip seems to be the most likely culprit) - but it happens to me maybe 2 or 3 times a week, and the headache is so slight that I just do my best to ignore it. For me at least, the Requip seems to "even out" my functionality and that effect seems to be cumulative as the day wears on. The day goes something like this: T+0: Take morning dose of Requip and Sinemet. T+20 minutes: Start feeling even slower and sleepier and slightly nauseated T+40 minutes: Slowness et. al. goes away; this happens very quickly, over the space of no more than a minute and I'm "on". T+3.5 hours: Start to notice that I'm slowing down. Take second doses. If there is a slow/sleepy/nausea period from this dose it is very short; most of the time I don't even notice one. Functionality just re-improves fairly rapidly and I've not really clocked it. T+8.5 to 9 hours: Start to notice I'm slowing down. But note that it is much longer than the duration of the on period from the first dose. Also my walking remains smoother and easier than when not medicated, even with the slowly increasing bradykinesia. Take third doses. Again, no significant slow/sleepy/nausea, functionality just slides up again. T+15 to 16 hours: Start to slow down again; again the duration of the useful on period seems longer than for the first two doses and again the walking remains good well into the increasing slowness. For me all I can say is that Requip is a much better deal than Permax was; during the Permax period I had almost constant G.I. discomfort (unless I under medicated myself) and Permax also made me depressed (or more depressed). John Stafford -- http://pw2.netcom.com/~johnws/index.html -- [log in to unmask] ................... Si fallatis officium, quaestor infinitius eat se quicquam scire de factis vestris.