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I've been having stiffness and slowness near the end of dose. I have been taking one mg. of Mirapex three times a day with one 50/200 Sinemet CR four times a day About three days ago, I decided to play doctor by cutting the one mg. Mirapex in half and taking them every four hours, instead of every eight hours. It may be all in my head, but I seem to feel better.Of course, my neurologist may not approve. I am going to give it another week or two and see what happens. Edie 63/l8.