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Janet, As a newbie, I think selegiline helped save my life. One of my main symptoms was fatigue along with muscular rigidity and limited range of motion in my right arm. Within 36 hours of my first dose I notice more zip in my step. And, within a month my fatigue and muscular rigidity had disappeared. This could be attributed to the amphetamines (or change of lifestyle). To stop taking selegiline might cause withdrawal pains; and, those withdrawal pains might be the return of the fatigue and rigidity I was experiencing prior to taking selegiline. Let's see. On one hand fatigue, muscular rigidity, and limited range of motion; and on the other hand we have selegiline. I don't think this is a close call. I guess, as long as I am "addicted" to PD, I will be "addicted" to selegiline. Larry Fleming 51/1 [log in to unmask] PS Should not you signature line be changing to 51/10 soon? -----Original Message----- From: PEwaschuk [SMTP:[log in to unmask]] Sent: Tuesday, January 06, 1998 11:54 PM To: Multiple recipients of list PARKINSN Subject: Re: meds for early PD - selegiline fact or opinion? hi brian; you wrote: >Hello Emily, my first reaction to your post was >'Well, even if I don't approve of everything, >they can't go far wrong at that early stage. >Now, having digested things for a while, >I do have some comments: >First ; Selegeline [sic]- don't feel guilty; It's not a major issue - >just remember that the 'anti-depressant is probably >the effect of the amphetamine (speed) >which is produced as the Selegeline [sic] breaks down, >so watch out or he'll be off partying all night! since i have taken selegiline [10 mg per day'] since diagnosis 9 years ago, i have not witnessed any such 'partying' tendency in myself nor have i read of any similar reaction in any of the medical studies that i have posted to the list brian, i do think it would be more helpful, especially when addressing a newbie to this 'designer disease' to qualify our statements about potential drug effects as being our own individual opinion/experience only and thus avoid the appearance of a sweeping generalization or declaration of fact as substantiated by the accepted medical journals [unless, of course, that is our intention] for factual information on any medication discussed here those of us with web access can: 1. search the archives of this list at simon coles' website 2. search the PubMed website provided by the US government a third option is: 3. request past postings of published news or medical studies from me when my 'real' computer is up and running again on a 'real' server we are all, miraculously, individuals with individual reactions and individual symptoms your cyber-sibling now in mississippi mills, ontario, canada janet janet paterson / 50-9 / sinemet-selegiline-prozac / [log in to unmask]