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from [log in to unmask]>com I Believe I"ve finally settled down on my adjustment to Maripex. I related early on in my treatment that it functioned extremely well, giving me much longer on times with good performance. Then after a few days at 3 ( 1 mg tablets tid) I experienced what I felt was reaction to this dosage. I now feel that is was most likely the suggested cutback of my routine dosages of sinemet 25/100 and CR 50/200 that caused the problems I was having. I contacted my neurologist and initially had me cut back the Maripex to 1/2 mg tid. I found that I had to return the dosage of sinemet to what I was taking before I started Maripex. and return the Maripex dosage to 3 ( 1 mg tablets TID). 25/100 &CR 50/200 Sinemet. i'm now back under control again. at least for now. I SEEM TO ALWAYS END UP DEPENDING ON SINEMET. i Learned that I cannot cut back on my sinemet at the dosages of maripex at 3 ( 1 mg tabs tid) Looking back appears easier to explain than at the time of stress. . i see my neurologist again on the 19th.. I' ll see what he wants to do about maintaining or increasing the Mariner . I think that the energy I get from Maripex lasts only about 4 hours and leaves me short 2 hours where i get quite drowsey. everything picks up for me shortly after taking the 2nd and 3rd doses. I hope this is helpful to others on maripex. I'm now planning to concentrate on anti-oxidents and other good ways to keep the brain cells healthy and/or protect and revitalize them and also slow or reduce the p.d. [log in to unmask] 58/13 Bi-pallodotomies 25/100 CR 50/200 & Maripex