Mary, Here is another study that I thought was interesting.
Also, my dad has rheumatoid arthritis and guess what!<smile>
They think rheumatoid arthritis is an autoimmune disease.
Linda Forrest's Mom
Pharmacol Toxicol 1997 Apr;80(4):159-166
The potential role of iron chelators in the treatment of Parkinson's
disease
and related neurological disorders.
Gassen M, Youdim MB
Neurodegeneration is characterized by a marked accumulation of iron in
the affected brain regions. The reason for this is still
unknown. In this article we review the available data on the possible
involvement of iron and mediated oxidative stress in the
aetiology of Parkinson's disease and related disorders. Iron chelators,
if they effectively prevent radical formation, have great
therapeutic potential against ischaemia/reperfusion, rheumatoid
arthritis, and anthracycline toxicity, which are most likely free
radical-mediated. The efficacy of the best established chelating drug
desferal in neurodegenerative disease is limited due to its
high cerebro- and oculotoxicity. New bioactive chelating agents are
currently being developed, among them are oxidative stress
activatable iron chelators which are most likely less toxic and can
flexibly respond to an increase of free radical formation in the
cell.
Publication Types:
Review
Review, academic
PMID: 9140134, UI: 97284857
Mary Thompson wrote:
>
> I have started to use a vitamin and mineral supplement containing
> antioxidant nutrients and antioxidant herbs after consultation with a
> naturopath. However I am still feeling a little uneasy about it.
> I was impressed by the paper titled: Prevention of dopamine-induced cell
> death by thiol antioxidants: possible implications for treatment of
> Parkinson's disease.
> Title Abbreviation: Exp Neural Date of Pub: 1996 Sep
> Author: Offen D; Ziv I; Sternin H; Melamed E; HochmanA;
> Issue/Part/Supplement; 1 Volume Pagination; 32-9
> Issue: 141
> I did note Linda Forrest's Mom's warning re N-Acetyl Cysteine and the
> failure of NAC to reduce low-density lipoprotein oxidiazability in healthy
> subjects.
> To cut a long story short, I have done some research of my own, but it sure
> is a jungle out there if your not a biochemist. So I will note down the
> ingredients of one tablet and ask any-one on the list serve who have a
> better understanding of antioxidants would be kind enough to browse through
> and tell me if there is any substance in these tablets that would be
> contra-indicated or suspect.
>
> One tablet contains:
> Quercetin 200mg
> Bromelain 1200 200mg
> Ascorbyl Palmitate 87mg
> d-Alpha Tocopherol Succinate 100iu
> L-Cysteine 50mg
> Retinyl Palmitate 5mg
> (equivalent Vit. A. 2500iu)
> Silyburn Marianum 36mg
> (equiv. to 25mg Silymarin)
> Betacarotene 30mg
> Zinc amino acid chelate 50mg
> (equiv. to 5mg elemental zinc)
> Manganese amino acid chelate 20mg
> (equiv. to 2mg elemental manganese)
> Ginko Biloba 10mg
> Copper amino acid chelate 8.33mg
> (equiv. to 500mcg elematal copper)
>
> Thank you in anticipation.
> Mary Thompson Melbourne Aus
> [log in to unmask]
>
> Regards Mary T. [log in to unmask]
