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Stephen, Co Q10 is generally used and reccomended for heart patients. Dr. Stephen Sinatra at Manchester, CT Hospital is a leading expert in the field. We heard him speak in Charlotte, NC last spring at Presbyterian Hospital. In my experience I have found that Pure Grape Seed Extract generally works very well with PD. My financee owns a medical co. that seems to have alot of PD patients, she has seen much success with Grape Seed Extract, in a pure form from a manufacturer in Mississippi. Much of the time many of their symptoms seem to diminish, or almost disappear, if you can believe that. Having been a Pharmaceutical Rep. myself, I am now leaning towards the "natural approaches" CoQ10, is an excellent heart med. although it is synthetic. Grape seed extract is pure and all natural. If you would like to contact her for more information, you can at [log in to unmask] Hope this helps, Steve Fazia.