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Hi, I am on the COMT inhibitor Tolcapon (brand name Tasmar) since October, i.= e. for more than 3 months meanwhile. As I can see from the postings only = a few members have access to this new drug. I think it might be useful for others to learn from my experience. I am 43 years old and was diagnosed with PD in 1989, which means now 9 years on drugs. In addition I should mention that I am still working at a= bank. Well, of course I suffer from fluctuations and dyskenisia. I have n= o tremor, but difficulties in walking, dressing, etc. yo know all these problems. Since I have the intention to limit the toxitity intake with t= he drugs (particularly Madopar =3D Sinemet in USA) I have developed a quite conservative and careful aapproach concerning levodopa. I am convinced th= at high levodopa intake makes the symptoms of PD even worse in the long run.= Before I started with COMT inhibitor tasmar I took 300 mg levodopa 2 mg Parkotil (pergolide, permax) 5 mg seligilin per day. Then I started with Tasmar. 3 x 100 mg per day. The first 8 weeks I only could reduce levodopa from 300 mg to 250 mg/day.= I had no side effects with Tasmar. It worked and works very fine on me. Aft= er 8 weeks Ii suddenly felt a push, which means I felt from one day to the other that 250 mg levodopa was too much. Meanwhile my levodopa intake is between 150 mg and 200 mg/day. I have following schedule: 07.00h: 50 mg l-dopa with 50 mg tasmar (plus a tea and a bread <s<) 08.00 h: seligilin 5mg plus parkotil 0,5 mg 10.00 h: 25 mg l-dopa plus 50 mg Tasmar 12.00h: 25 mg l-dopa plus 50 mg tasmar plus 0,25 mg seligilin plus 0,5 mg= Parkotil (during or before lunch) 15.00h: 25 mg l-dopa plus 50 mg tasmar plus 0,5 mg parkotil 18.00: 25 mg l-dopa plus 50 mg tasmar plus 0,5 mg parkotil 20 h: 25 mg l-dopa plus 50 mg tasmar = My conclusion: To limt levodopa (Madopar/sinemet) to smallest dosis posssible. Tasmar extends the duration of l-dopa in blood by 40 % in my case and I take l-dopa only together with tasmar Parkotil as agonist works well on D2 receptor and I take it in addition t= o COMT inhibitor tasmar and MAOB inhibitor seligilin. With a daily intake of 175 mg levodopa plus 2 mg agononist substance I fe= el not healthy but well enough to work und pursue a reasonable adequate life= =2E My strong recommendation therefore: if you can convince your body to get along with tasmar: GO FOR IT. You should be able to reduce levodopa by 40= %. As I told you, it might take a few months to reach breakthrough, in my= case 2 months. Due to comt inhibitor I feel more optimistic. I should add that Ii do not= overdo my activities, which means I take a rest in morning and afternoon (my employer has made available special room for me to rest - a nice gesture). Hope it was of some ineterest to hear from a German about his tasmar experience. regards Dietmar (43/9)