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Sonia and Rosemary Thanks very much for your responses to my recent posting. Rosemary, glad to read you are getting on well on Tolcapone and managing to work full time. As I said previously, I think I have more stamina now and hope this will continue as I find the fatigue, which goes with PD, very frustrating when you are trying to lead an active life. Sonia, again sorry you are not having such good results but I do admire you for your positive outlook and hope that maybe, with the latest change in meds, you find you improve. Best wishes Susan HC 44/12 UK