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This is a multi-part message in MIME format. --------------76B210167E6CF45E726945EE Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit Dear Linda, Many thanks for your rapid and very interesting reply. I will be in touch. I hope to read your e-mial in greater deepth this eveing. Thanking you again, Gerald Linda Carlton wrote: > Hi! Gerald, I have clipped some messages together, just some notes > on what I have found out about herpes and PD. Sorry I am so busy > these days and I have not had time to put it all together. I hope > they make some sense. Best Wishes, Linda Forrest's Mom > And remember this is just a theory. Detecting Herpes Simplex Virus > in brain tissue is very difficult and can or will sometimes result > in a false-negative testing. Yet, Herpes Simplex is just one of > the members of the herpes family that can cause CNS damage. > > As a recent intestinal-permeability study showed, "familial" does not > always imply "genetic". Interestingly, a gene-therapy being tried for PD > is based upon "attenuated" herpes-simplex-virus as the carrier. Why? > Because HSV can travel into monoamergic neurons, including those > affected in PD. > > <2> Sanders VJ et al. > PRESENCE OF HERPES SIMPLEX DNA IN SURGICAL TISSUE FROM HUMAN EPILEPTIC > SEIZURE FOCI DETECTED BY POLYMERASE CHAIN REACTION - PRELIMINARY STUDY > Archives of Neurology. 54(8):954-960, 1997 Aug. > Objectives: To determine whether herpes simplex virus causes monofocal > epilepsy and to assess the presence of herpes simplex virus 1 (HSV-1) > and HSV-2 in surgical specimens from patients with epilepsy by using > polymerase chain reaction and Southern blot analysis. > Background: Herpes simplex virus is a common neurotropic virus capable > of latency within the central nervous system; it has a predilection for > the temporal lobe. Central nervous system infection with HSV has been > associated with seizure activity. > Design and Methods: Surgical specimens were removed from 50 patients > as part of a treatment protocol for monofocal epilepsy. > Neuropathological classification was done, and adjacent sections were > screened for HSV by using polymerase chain reaction. Tissues obtained > post mortem from the temporal lobe cortex of persons with Alzheimer > disease (n = 17), Parkinson disease (n = 14), or nonneurological disease > (n = 17) served as controls. > Results: Twenty (40%) of the 50 epilepsy cases and 2 (4%) of the 48 > control cases had at least one sample that tested positive for HSV (P > <.001). Sixty-seven percent (8/12) of the epilepsy cases with > heterotopia were positive for HSV. > Conclusions: There was a statistically significant difference in the > frequency of HSV-positive surgical specimens from monofocal seizure > epicenters compared with nonepilepsy control specimens. These data > suggest an association of the virus with seizure activity. All specimens > positive for HSV (surgical specimens and control specimens) should be > examined to determine the activity or latency state of the virus and > cellular localization. [References: 21] > > Gerald P. Connolly wrote: > > > > Dear Larry, > > > > My Partner is suspected of having PD, to be tested next month. > > She has had chicken pox when young, and shingles recently. > > She seemed to develope PD about 6 months latter and has never been her old > > self. since then. > > Please keep me informed of your findings. > > I belive there is a virus-infection that can trigger PD? > > Any info. most wellcome. > > > > Gerald > > > > Flemco- wrote: > > > > > Dear Listmembers, > > > > > > The following is from Encarta: > > > Herpes Zoster > > > > > > "Known as shingles, this is a one-time recurrence of the symptoms of > > > chicken pox, usually during adulthood. It is caused by the chicken pox > > > virus attacking a sensory nerve. The skin over the nerve generally breaks > > > out in blisters a few days after the onset of the disorder, which is > > > accompanied by pain and frequent numbness or hypersensitivity along the > > > course of the nerve, usually the trunk. The blisters are at first clear, > > > but become cloudy within a few days and form crusts that dry up after five > > > or ten days. > > > The skin manifestation of herpes zoster is not serious, but the pain caused > > > by the inflammation of the underlying nerve can be severe, lasting for > > > weeks; recovery may be followed by persistence of neuralgia in the area of > > > the involved nerve. High doses of acyclovir can significantly reduce the > > > symptoms of herpes zoster. Normally, medication relieves pain, and the > > > disease subsides spontaneously. More severe cases may be treated with such > > > steroids as cortisone. In cases of persistent pain, the involved nerve may > > > be either blocked by drugs or cut." > > > > > > I had shingles and chicken pox as a child and shingles again in my > > > mid-30's. I remember my adult episode occurring during a period of > > > extraordinary stress in my life (job and family related). As a child, I > > > don't know what I was stressed about. > > > > > > Have any of you suffered from shingles and do you suspect any relationship > > > with PD? > > > > > > How many have had chicken pox? > > > > > > Did we not have some postings this past fall concerning herpes? > > > > > > Any comments? This is not intended to be a survey. I was just curious and > > > wondered if others had similar experiences. > > > > > > Larry Fleming 51/1 > > > [log in to unmask] > > > > ------------------------------------------------------------------------ > > > > Dr. Gerald P. Connolly <[log in to unmask]> > > > > Dr. Gerald P. Connolly > > <[log in to unmask]> > > Purine Research Lab, Work: 0171-955-8718 > > London Bridge, Fax: 0171-407-6689 > > LONDON Netscape Conference Address > > UK > > SE1 9RT > > ENGLAND > > Additional Information: > > Last Name Connolly > > First NameDr. Gerald P. > > Version 2.1 --------------76B210167E6CF45E726945EE Content-Type: text/x-vcard; charset=us-ascii; name="vcard.vcf" Content-Transfer-Encoding: 7bit Content-Description: Card for Dr. Gerald P. Connolly Content-Disposition: attachment; filename="vcard.vcf" begin: vcard fn: Dr. Gerald P. Connolly n: Connolly;Dr. Gerald P. adr: Purine Research Lab, ;;London Bridge, ;LONDON;UK;SE1 9RT;ENGLAND email;internet: [log in to unmask] tel;work: 0171-955-8718 tel;fax: 0171-407-6689 x-mozilla-cpt: ;-17216 x-mozilla-html: FALSE version: 2.1 end: vcard --------------76B210167E6CF45E726945EE--