At 08 Don: Do you mean you started at 3.75 mg? Most of us have eased in to this with tiny amounts. Even now he takes 1.5 mg in three stages daily. He has decreased his Sinemet a 1/3. Gord is one who has taken Sinemet for 20 years. Anywa, that's how it has worked for him. Gordon and Thea Seese [log in to unmask] net Mt. shasta, Ca.