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I am prepared to take Tami's word that she is genuine in her wish to introduce PWPs to a (relatively) cheap supplier of NADH. And I am sure she is sincere in looking for a way to alleviate her husbands PD. I don't wish to get into the argument of who said what to whom and why, but I would like to make some comments about NADH. 1. The original paper by Dr. Birkmayer in 1993 shows that his study was of only 17 PD sufferers, with no non-PD controls. 2. He states in a later paper (1995) that FDA-approved studies were to take place in the US. He also states that further studies were to take place in Europe. To the best of my knowledge, no such studies exist. 3. During the application of NADH by Dr. Birkmayer, the patient's previous medication regimen, ie, l-dopa etc., was *continued*. In other words, there was no attempt to take the sufferers off their prior medication, and test them on NADH alone. 4. The greatest "improvement" was among those sufferers youngest in age and had the shortest duration of PD. 5. When carbidopa was added to the treatment, the observed effects were better and longer lasting, which suggests a peripheral action of NADH, rather than direct stimulation. 6. There were no bio-chemical tests made of the sufferers, but the results were calculated on the way that the participants "felt", and how much better they "remembered things". 7. A "placebo" effect has been postulated as the relevant factor, given the lack of control subjects, and the lack of "double-blind" testing. 8. On this slim evidence, several suppliers of vitamin/mineral supplements etc. have prepared a range of NADH-containing products, (usually highly-priced), and have advertised extensively, including quoting each other's "findings" as proof of the efficacy of NADH. 9. NADH is produced as a result of the reduction of nicotinamide, one of the B vitamins. One of the most popular of the NADH-containing products also contains pantothenic acid, another of the B vitamins, and adenosine triphosphate, the "wonder" ATP, which is supposed, according to the literature, to be produced by NADH! 10. NADH is closely related to niacin, another member of the vitamin B family. 11. All members of the vitamin B complex are found in abundance in meat, poultry, fish, etc. 11. Glucose, the "wonder cell food", is a naturally-occurring food substance, sometimes seen as dextrose, or corn syrup. So it seems that one could perhaps achieve the same effects with a dish of fried chicken and a plate of pancakes with syrup. I know that would certainly make me feel better. I leave it up to other PWPs to make up their own minds. However, I wouldn't go to www.nadh.com for information on the subject. I have rarely seen a greater mish-mash of poorly-understood science, pseudo-scientific mumbo-jumbo, unsupported "evidence" and general bulldust as this site presents in an attempt to convince people to part with their money. And no, I am not a doctor, nor a pharmacist, nor do I make any money in any way from prescription, or any other medications. And no, Don, I am not angry over all this, just saddened. Jim 59/13 [log in to unmask]