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Dear List members, I send this not to be a scaremongerer - all drugs have side or adverse affects, merely because I have been researching it and thought that some may find it interesting. If anyone has read of any other - particularly the unusual or serious side effects - please let me know - and send references please. Many thanks Joy Graham ................................. Side Effects of Pergolide (Permax) References 1. Current Trends in the Treatment of Parkinson's Disease, Ed. Yves Agid, John Libby & Co. Ch, 10 pp 93-103, Adverse Effects Dyskinesia Erythromelalgia (red, tender, warm and oedematous legs) Nausea Hallucinations Lupus - like syndrome (rarely) Paranoid ideation Pulmonary and retroperitoneal fibrosis Rhinitis Dystonia Drowsiness Postural hypotension Dyspepsia Dyspnoea From Current Trends... ch 8, pp 80 -81 As above plus Constipation "elevated liver function enzymes defined as 2-3 times the normal ranges for AST/SGOT and ALT/SGPT in 1% of patients treated with Pergolide. Eight patients discontinued from the studies because of elevated liver enzymes. Two young patients enrolled in the endocrine studies developed hepatitis while being treated with Pergolide." 2. From Pergolide: A Review of its Pharmacological properties and Therapeutic Potential in Parkinson's Disease, Heather Langtry & Stephen Clissold, Adis Drug Info. Services, Auckland, 1990 In addition to the above adverse reactions this reference quotes: Anxiety abdominal pain headaches abnormal vision worsening of cardiac status (changes in cardiac rhythm, bradycardia)