My wife Aliza (74/3)has been taken to task for taking Nutritional Supplements to ease her PD symptoms on the grounds that it is being done on her own without professional medical supervision.Family members with a technical professional background(biochemistry,physical therapy) are concerned about possible interactions with the drugs she is taking and associated dangers.They argue that supplements have not been properly evaluated as to effectiveness and risks,documented and reviewed by peer groups in the customary way.Therefore she should stay away from using them. Aliza has heeded this criticism and has stopped all supplements except multivitamins and calcium/magnesium pills. In recent months,after stopping taking supplements like NADH,pycneganol, vitamin E,L-Carnitine,grape seed extract(PCO Phytosome),Acetyl-L-Carnitine, Taurine,hawthorne berry capsules,and stopping taking selegiline,her PD symptoms have gotten significantly worse.As her CG,I felt she was being helped but she is now afraid of supplements.At one point she took acetyl-L cysteine and later learned about detrimental effects and stopped. I am wondering whether we can pool our info sources and organize the information we have about the effectiveness and risks of specific supplements as well as interactions. Perhaps this has already been done? What do the neurologists have to say about supplements? When we brought this up with Aliza's neuro ,his response was that he doesn't know and doesn't want to know. Warm regards to everyone. Gil Lieberman,75, CG for Aliza 74 ,PD 3 years