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For what it's worth: I've had PD for about 22 years, am 55 years old, have had a unilateral pallidotomy (10/24/94) and have used an estrogen patch for ERT (estrogen replacement therapy) for the last 10 years (had a hysterectomy 10 years ago). While I don't know if your MD will consider putting you on an estrogen supplement if you're still ovulating, that certainly would provide you with a steady, regulated amount of estrogen all day, every day. I have ONE negative interaction (or REaction?) between the estrogen and the PD and/or Sinemet. That ONLY happens on those rare occasions when I forget to change to a fresh estrogen patch once a week at the proper time and my system runs low or out of the estrogen. THEN I get a bit shaky until I put on a new estrogen patch, and within a short time my system returns to it's "normal Parkie state." Barb Mallut [log in to unmask] ---------- From: Parkinson's Information Exchange on behalf of Tsupug Sent: Thursday, January 22, 1998 9:55 AM To: Multiple recipients of list PARKINSN Subject: hormonal therapy for young-onset women? Hi- I am new to the list and really enjoy it. I was diagnosed with PD at age 30 (six years ago) although I've had symptoms since my first child was born (11 years). I have severe on/off response to PD meds and had a unilateral pallidotomy 2 years ago, which helped considerably. I still have dyskinesis on the untreated side. I do so much better (PD symptoms) during my ovulation time and terrible around the pre-menstrual time. My question: oes anyone know, or have heard about, a way to keep hormonally balanced during the whole month? The difference between the times of the month and my PD symptoms are like night and day. Thanks for your input!! P.S. One more note: after my second child was born in 1990, my symptoms worsened considerably, which seems to verify some hormonal link.